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If Your Skin Can’t Handle Retinol, Try Retinyl Palmitate

tiny capsules spilling from a jar

You’ve likely heard of retinol, and may even be using one as part of your skincare routine. But allow us to introduce you to retinyl palmitate, retinol’s slightly less intense cousin. Confused? We can explain. Retinol is actually one of four types of retinoids commonly used in skincare; there’s also retinoic acid, retinaldehyde, and, the current topic of conversation, retinyl palmitate. While they’re all vitamin A-derivatives with similar benefits, they’re not identical. There are some key differences between them, particularly when it comes to how well your skin can tolerate each ingredient—an important factor since retinoids are notorious for their irksome side effects.


  • Sheel Desai Solomon, MD, is a board-certified dermatologist based in Raleigh-Durham, NC.
  • Ted Lain, MD, is a board-certified dermatologist and chief medical officer specializing in the diagnosis and treatment of disorders of the hair, skin, and nails.

And (spoiler alert) if you have sensitive skin, retinyl palmitate is your best bet. Here, dermatologists explain what makes this ingredient unique.



MAIN BENEFITS: Promotes skin cell turnover, improves skin tone, helps unclog pores, helps thicken the dermis to slow down the formation of wrinkles.

WHO SHOULD USE IT: Because retinyl palmitate is the least irritating of all four retinoids (more on that in a minute), it’s a great option for almost all skin types and anyone who wants to keep their pores clear and skin youthful, says Solomon. It does still have the potential to be somewhat irritating for those with extremely sensitive skin, however.

HOW OFTEN CAN YOU USE IT: While it’s important to ease into things to let your skin gradually acclimate to the ingredient, it can ultimately be used daily.

WORKS WELL WITH: According to Lain, “Retinoids have a synergistic effect with antioxidants such as vitamins C, E, and ferulic acid.” Pairing any retinoid with sunscreen is also important since it may make your skin more susceptible to the sun.

DON’T USE WITH: Since retinyl palmitate has exfoliating properties, avoid combining it with other chemical exfoliants, such as glycolic or salicylic acid, as well as harsh scrubs with abrasive ingredients, cautions Lain. This holds especially true if you fall into the super sensitive skin camp. It can also cause some dryness, notes Solomon, so it’s a good idea to pass on toners and astringents, too.

What Is Retinyl Palmitate?

Before we get to the specifics, it’s important to talk about the larger category of retinoids in general. There are four commonly used in skincare, all of which are derivatives of vitamin A and have similar effects, aka speeding up cell turnover on the surface of the skin for a smoother, more even texture, while also working on the deeper layers to stimulate collagen production and fight wrinkles.1

On one side of the spectrum is retinoic acid. Also known as tretinoin, it’s available only with a prescription and is undeniably the most potent of the bunch. “Retinoic acid is the most active and effective retinoid, but also has the highest potential for irritation,” explains Solomon. On the opposing end is over-the-counter retinyl palmitate, which dermatologists agree is notably less effective (though that’s not necessarily a bad thing). “Retinyl palmitate can be a better option for some because it’s less irritating,” points out Solomon. It’s less effective, but will be more comfortable to use consistently and continually, she adds. Also of note: Retinol and retinaldehyde, are available OTC and fall somewhere in the middle in terms of efficacy and irritation.

Benefits of Retinyl Palmitate for Skin

Just because it’s less effective than its counterparts doesn’t mean it’s not doing anything for your skin—we are, at the end of the day, still dealing with a retinoid. Like its fellow retinoids, retinyl palmitate acts both on the surface and within deeper layers of the skin.

  • Speeds cell turnover: “It causes the cells on the epidermis—the outermost layer of the skin—to rapidly turn over and die. This sounds sinister, but it makes way for new cell growth underneath,” says Solomon.
  • Brightens skin: The exfoliating aspects of the ingredient may result in smoother, more radiant skin with less discoloration and an overall more even tone.
  • Lessens the appearance of wrinkles: Retinoids hinder the breakdown of collagen. It also thickens the epidermis and dermis, which is where wrinkles begin to form, says Solomon.
  • Antioxidant properties: Retinyl palmitate can help with antioxidant protection of the skin.2
  • Stimulates collagen production: And besides inhibiting collagen breakdown, it also stimulates new collagen: Once retinyl palmitate is converted to retinoic acid in the skin, it binds to specific receptors in the cells that lead to increased collagen production, according to Lain.
  • Keeps pores clear: In speeding up cell turnover and acting as an exfoliant, as previously mentioned, it may also help unclog pores and keep them clear, which is why it’s often found in acne treatments.
  • Available over-the-counter: Unlike some super skincare ingredients, products containing retinyl palmitate are available in most beauty and drugstores.
  • Quickly absorbing: As it is a retinol, retinyl palmitate is easily absorbed by the skin.1

Retinyl Palmitate vs. Other Retinoids

It’s easy to look at retinoids on a scale of intensity: If prescription-strength retinoic acid packs a hardcore punch, then retinyl palmitate delivers more of a gentle tap. Retinoic acid is the only form that your skin can utilize, so if you’re using it straight up, your skin gets it immediately. Retinyl palmitate, on the other hand, needs to undergo a conversion process. “Once it’s absorbed into the skin, enzymes convert it to retinoic acid, the biologically active version that has the beneficial effects,” says Lain.

This process reduces its efficacy, which is why it’s the least effective of the bunch (retinol and retinaldehyde also get converted to retinoic acid, but it’s a more direct process, which makes them more intense). Still, the reduced potency is what makes it so much easier for your complexion to tolerate retinyl palmitate.2 If you have highly tolerant skin and/or want to see results ASAP, you may want to go for the strong stuff. But, if you’re new to retinoids or have sensitive skin, retinyl palmitate is your best bet.

Side Effects of Retinyl Palmitate

Comparatively speaking, retinyl palmitate is pretty gentle, so side effects are rare, though they can still happen. Expect the same ones you’d have with any retinoid, namely: itching, burning, peeling, and increased skin sensitivity, all of which are more likely the more sensitive your skin is.3

How to Use It

Retinoids are often deactivated by sunlight and can make the skin more sensitive to the sun, cautions Lain. So first and foremost, make sure to always reserve retinyl palmitate for nighttime use (this is made easier by the fact that it’s often found in night creams and serums). To that point, be extra diligent about using a broad-spectrum sunscreen with at least an SPF 30 during the day as well.

Slow and steady is the name of the application game. Just like you wouldn’t run a marathon without proper training, give your skin time to get used to the intensity of this ingredient. Lain recommends applying a small amount to a quarter-sized area on your lower cheek every other night for a week, followed by a moisturizer. “If there’s no redness or irritation on this test spot, then you can start applying it to your entire face, but still just three times per week,” he says. After two weeks, you can step it up to nightly application.

Anytime you use a product with retinyl palmitate—or any retinoid, for that matter—pair it with a plain moisturizer (basic is best, avoid any formulas with intense active ingredients). Apply the retinoid product on clean skin, then top it with the moisturizer. This may help minimize the likelihood of any of those pesky side effects, particularly among the sensitive skin crowd.

The Best Products With Retinyl Palmitate

dermae wrinkle cream
DermE Anti-Wrinkle Renewal Cream $13.00


Both derms recommend this product, which also happens to be super affordable. In addition to the retinyl palmitate, it’s enriched with vitamin E, allantoin, and panthenol to help nourish and intensely moisturize skin, says Solomon.  

Essential-C Day Moisture Broad Spectrum SPF 30 | PA+++
Murad Essential-C Day Moisture $68.00


“This product repairs existing photodamage and fortifies skin against future damage while reducing the appearance of fines lines and wrinkles,” says Solomon, who adds that it’s a great multi-tasker to use not only on your face but on your neck and chest, too. It contains vitamins C and E, antioxidants that work well with retinyl palmitate, according to our experts.

Shani Darden Retinol Reform Serum
Shani Darden Retinol Reform $88.00


This was the product that finally convinced one Byrdie editor to hop aboard the retinoid train. Using it at night left her skin, “fresh” and “glowy,” and she claims the fine lines that cropped up on her face eventually diminished. Credit that gentle retinyl palmitate, coupled with hydrating sodium PCA and soothing aloe.

Retrouve Revitalizing Eye Concentrate $215.00


The skin around your eyes is thinner than other areas, which is why it may be where fine lines and wrinkles show up first. Enter this luxurious balm-like formula that pairs the anti-aging benefits of retinyl palmitate with heavy-hitting hydrators such as ceramides and jojoba seed oil, all with a silky texture that glides across this delicate skin.

Elizabeth Arden Ceramide Capsules Daily Youth Restoring Face Serum
Elizabeth Arden Advanced Ceramide Capsules Daily Youth Restoring Serum $109.00


Pairing retinyl palmitate with ceramides, essential ingredients meant to help maintain a strong and healthy skin barrier, may minimize the likelihood of irritation. The pre-dosed capsules make application easier than ever, (not to mention, they are ideal for travel).

pestle and mortar superstar night oil
Pestle & Mortar Superstar Retinoid Night Oil $104.00 $90.00


If you want to take your retinyl palmitate game up a notch, try this oil, which combines the ingredient with another new type of retinoid known as HPR meant to maximize the pore-minimizing, wrinkle-reducing effects, according to the brand. Organic, cold-pressed oils round out the ingredient list, making for a fast-absorbing yet deeply hydrating formula.

Seacret body lotion
Seacret Milk and Honey Body Lotion $23.00


Retinyl palmitate isn’t beneficial just for your complexion: Solomon is a fan of this hydrator for the skin below your chin. “Along with retinyl palmitate, it also has other great key ingredients such as avocado oil and chamomile extract,” she says. She also points out that it’s paraben-free and hypoallergenic, and that the formula absorbs quickly without ever feeling greasy.

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